1-RGD contained a tumor-targeting cyclic peptide (cyclic Arg-Gly-Asp, c-RGD), 2-cyano-6-hydroxyquinoline (CHQ), a D-cysteine (D-Cys) residue, a caspase-3-cleavable peptide substrate (Asp-Glu-Val-Asp, DEVD), a glutathione (GSH)-reducible disulfide bond, and a clinically used NIR dye (indocyanine green, ICG) (Figure 2a) [66]. This evidence concerns the gene CASP3 and neoplasm.