MMP2 and breast cancer: At a concentration of 50 g/mL, the aqueous TO root extract inhibited and reduced the cell viability of MCF-7/AZ breast cancer cells by 50% via inhibition of the dual kinase complex focal adhesion kinase (FAK)-steroid receptor coactivator (Src) and downregulation of matrix metalloproteinases MMP-2 and MMP-9 [84].