STAT3 and Arthritis: Additional reports also revealed that polydatin downregulated the retinoic acid receptor-related orphan receptor gamma t (RORγt) and signal transducer and activator of transcription 3 (STAT3) gene expression, attenuated IL-17 production against CD3/DC28-induced peripheral blood mononuclear cells and arthritis [11,56], and ultimately reduced both the NF-κB and vascular endothelial growth factor (VEGF) as well as the circulating levels of the downstream inflammatory cascade including IL-6, TNF-α [56].