Additionally, a study carried out in DSS-induced colitis provided reliable evidence that APS attenuates murine colitis through the inhibition of the NOD-like receptor protein 3 (NLRP3) inflammasome, which acts to reduce the production of inflammatory cytokines such as interleukin-18 and interleukin-1β [15]. The gene discussed is NLRP3; the disease is colitis.