The oral intake of a polysaccharide extracted from Hericiumerinaceus (HE) can reduce intestinal inflammation in a DSS-stimulated colitis model by adjusting the production of NO, MDA, T-SOD, and MPO to repair the oxidative damage of the mucosal barrier, and down-regulating the expression of COX-2, iNOS, and cytokines via blocking NF-kB, MAPK, and PI3K/AKT signaling pathways [26]. The gene discussed is MPO; the disease is colitis.