However, oxygen and glucose deprivation in ischemic stroke results in excessive ROS, and then Nrf2 is activated and released from keap1 into the nucleus to bind to antioxidant response elements (ARE) in order to regulate the expression levels of several antioxidant enzymes; on the other hand, Nrf2-downstream proteins can mitigate the deleterious effects of oxidants produced in excess during reoxygenation [16,19]. Here, NFE2L2 is linked to ischemic stroke.