AKT1 and cancer: To sum up, we have reviewed the anticancer effects of magnolol against various cancer types and elucidated its main underlying pharmacological mechanisms, including proliferation inhibition, cell cycle arrest, apoptosis induction, metastasis blockage, angiogenesis inhibition, and pathways involving in PI3K/Akt/mTOR, MAPK and NF-κB signaling (Table 1 and Figure 2).