AKT1 and cancer: In recent years, there are a number of studies reporting the anticancer effect of magnolol, which exhibited a wide range of pharmacological mechanisms against cancer, including proliferation inhibition, cell cycle arrest, apoptosis induction, metastasis blockage, angiogenesis inhibition and signaling pathways involving phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/Akt/mTOR) signaling, mitogen-activated protein kinase (MAPK) signaling and nuclear factor kappa-B (NF-κB) signaling.