DACT2 and colorectal cancer: Lu et al. (2018) found that Kae increased DACT2 expression in colorectal cancer cells HCT116, HT29, and YB5 by DACT2 demethylation through the suppression of DNMT1 and DNMT3b expression, thereby inhibiting the nuclear β-catenin expression and deactivating Wnt/β-catenin pathway proteins [109].