AKT1 and Familial prostate cancer: In the same way, Qi, Sti, and Kae induce apoptosis by inhibition of PI3K phosphorylation [88,135,136], and Iso down-regulated the expression of p-PI3K, p-Akt, and p-mTOR inhibiting cell migration and invasion by matrix metalloproteinases regulation in prostate cancer [137] and skin cancer cells [121].