Furthermore, treatment with flavonoid-rich extract of P. capitatum (the major constituents were luteolin-7-O-glucoside, rutin, and quercitrin) at 90 and 180 mg/kg body weight in rats for 6 weeks remarkably decreased serum TNF-α, and interleukin-6 (IL-6) levels, which mechanism implied that total flavonoids suppressed the development of atherosclerosis, possibly by inhibiting inflammatory response [7]. The gene discussed is IL6; the disease is atherosclerosis.