Unlike other natural extracts, the rhizome of ginger (Zingiber officinale), a common culinary agent, is known for its caspase-independent paraptosis in triple negative breast cancer (MDA-MB-231) and non-small lung (A549) cancer cells via ER stress, mitochondrial dysfunction, AIF translocation and DNA damage [83]. The gene discussed is AIFM1; the disease is triple-negative breast carcinoma.