A substantial (p < 0.0001) downregulation in IL-4,-10, and I-κBα expression in the diseased control group (IL-4: 31.27 ± 1.12%, IL-10: 37.09 ± 0.9%, I-κBα: 55.24 ± 1.04%) in comparison to normal group in CFA induced polyarthritis. The gene discussed is IL10; the disease is polyarticular arthritis.