Combing our further investigation on MORC2-related functions and pathways, our results reveal that MORC2 is upregulated in CRC, decreased MORC2 inhibited tumor proliferation and colony formation in vitro, as well as tumorgenesis in vivo, and further impacted cell senescence via regulating the HDAC4/P53 pathway. This evidence concerns the gene HDAC4 and colorectal carcinoma.