In this context, the screening results revealed that glycoalkaloid, steroids, triterpenoids, solanine, and flavonoids were the main phytochemical bioactive compounds of S. surattense that proved potent in the development of HCC by affecting the TP53, GAPDH, AKT1, ESR1, EGFR, TNF, HIF1A, HRAS MTOR, and BCL2L1 gene targets. Here, EGFR is linked to hepatocellular carcinoma.