The anti-cancer effects of S. surattense on HCC were postulated to be associated with the regulation of tumor cell proliferation, apoptosis, angiogenesis, tumor invasion, and metastasis via multiple signaling pathways, including the AKT1, EGFR signaling pathway, the ESR1 signaling pathway, and the HIF1A signaling pathway. This evidence concerns the gene HIF1A and hepatocellular carcinoma.