Jia et al. found that icariin can induce autophagy and reduce renal fibrosis in the DKD models, and its mechanism is related to the reduction of miR-192-5p, its overexpression inhibited glucagon-like peptide 1 receptor (GLP-1R), induced p-mTOR expression, and increasing the expression of collagen I, α-SMA, and FN. Here, GLP1R is linked to renal fibrosis.