Resveratrol can activate sirtuin1 (SIRT1), increase the expression of SIRT1 and peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) in renal tissue of DKD mice, reduce the production of mitochondrial ROS, and increase mitochondrial membrane potential, thus improving podocyte damage in diabetic mice [59]. This evidence concerns the gene PPARGC1A and diabetic kidney disease.