Another study found that resveratrol improves lipid metabolism in STZ-induced DKD by inducing AMPK/mTOR-mediated autophagy, at the same time, resveratrol alleviates lipid dysregulation by increasing the level of lipid oxidation-related protein such as peroxisome proliferator-activated receptor-alpha (PPARα) and carnitine palmitoyltransferase I (CPT1), and reducing the level of lipid production related protein such as sterol regulatory element-binding protein(SREBP)-1c and acyl-CoA synthetases (ACS) in DKD [63]. This evidence concerns the gene CPT1C and diabetic kidney disease.