Research has found that fisetin reduced the EMT process, alleviated HG-induced podocyte injury and STZ-induced DKD, which is related to the restoration of cyclin-dependent kinase inhibitor 1B (CDKN1B)/P70S6K mediated autophagy and the inhibition of the NLRP3 inflammasome [171]. This evidence concerns the gene CDKN1B and diabetic kidney disease.