Nrf2 is an important endogenous antioxidant transcription factor that protects cells from ROS injury, several studies have indicated that Nrf2 activators such as resveratrol have protective effects against DKD, resveratrol reduces oxidative stress, cell hyperproliferation, and ECM accumulation in mouse glomerular mesangium by activating the Keap1/Nrf2 signaling pathway [60]. This evidence concerns the gene KEAP1 and diabetic kidney disease.