LDLR and metabolic syndrome: Dyslipidemia is one of the most serious and frequently occurring complications in DKD patients, lipid accumulation in the kidney has also been considered to play a role in the pathogenesis of DKD [129], Jiang et al. found that there were a large number of lipid droplets of different sizes in the renal cortex of diabetes mice, and quercetin could effectively reverse the lipid accumulation in both glomerulus and renal tubular cells by SREBP cleavage activating protein (SCAP)-SREBP2-low-density lipoprotein receptor (LDLr) signaling pathway [130].