In the process of kidney diseases such as DKD, excessive ROS causes renal function damage, Keap1 increases, and Nrf2 activation decreases, reduce the production of antioxidant related proteins, such as superoxide dismutase(SOD)-1, heme oxygenase (HO)-1, and catalase (CAT) [29]. The gene discussed is HMOX1; the disease is diabetic kidney disease.