CRYBG3 and lung cancer: They loaded porous iron oxide nanoparticles (PIONs) with pcDNA3.1−vector−encoding long noncoding RNA crystallin beta−gamma domain−containing 3 (LNC CRYBG3) to overexpress LNC CRYBG3 in tumor cells for degrading the actin cytoskeleton, and inducing cell apoptosis, resulting in the effective destruction of non−small−cell lung cancer cells in vitro and in vivo (Figure 5) [103].