With regard to our initial question, if AQPs could be used as reliable prognostic indicators in ADC, it has to be said that, for instance, in hepatic cancer, the immunohistochemical detection of AQP1 represents a reliable way to differentiate between cholangiocarcinoma, hepatocellular carcinoma, and metastatic colorectal carcinomas. This evidence concerns the gene AQP1 and hepatocellular carcinoma.