Further, we showed that AQP3 was distinctively expressed in the cytoplasmic membrane of cancer cells in 65 of 79 lung carcinoma biopsies (Figure 1B,C), whereas in non-neoplastic lung samples, AQP3 was localized in basolateral plasma membranes of the surface epithelium (Figure 1A). Here, AQP3 is linked to lung carcinoma.