Marfan’s is associated with mutations in the Fibrillin-1 gene, FBN1; other phenotypic variants such as marfanoid progeroid lipodystrophy syndrome, and neonatal progeroid syndrome form part of this group of ‘fibrinillopathies’ and are associated with depletion of asprosin, consequently encoded by the final two exons of FBN1 [68,69]. Here, FBN1 is linked to Wiedemann-Rautenstrauch syndrome.