Compared to ALK− tumors, ALK+ tumors showed significantly weaker TLS formation, reflected by the lower TLS density (Figure 3B,G), lower TLS/tumor (Figure 3C,G), and lower densities of all main TLS-ICs, including tB cells (Figure 3D,H), tTh cells (Figure 3E,H), and tCTL (Figure 3F,H). The gene discussed is ALK; the disease is neoplasm.