Specifically, C3M, C4M, and PRO-C4 levels increased in the DSS induction phase and declined in the healing phase without DSS, while rodent-PRO-C3 showed a declining tendency after induction of colitis and an increasing tendency after receiving regular water, resulting in increased turnover of type III collagen (C3M/PRO-C3 ratio) [39]. The gene discussed is C4A; the disease is colitis.