For example, exercise may improve the redox state of brain tissue by exerting anti-inflammatory effects, thus improving some physiological characteristics of AD (e.g., increasing the clearance of amyloid plaques and tau protein) [59,60]; and it may have a positive impact on cognitive function and brain structure [61], by promoting the release of BDNF [62,63,64]. The gene discussed is BDNF; the disease is Alzheimer disease.