In some studies conducted among adults, it has also been demonstrated that significant effects on ghrelin secretion from the stomach are exerted by diseases, concomitant to H. pylori infection, such as peptic ulcer, gastric cancer and antral gastritis, or occurring without H. pylori infection, such as atrophic gastritis, affecting both stomach fundus and body [44,45,46]. This evidence concerns the gene GHRL and peptic ulcer disease.