Patients with a severe form of periodontal disease presented higher bacterial loads in atherosclerotic plaques compared to those with medium periodontitis [88] It was demonstrated that the periodontal disease condition triggers the production of inflammatory mediators and clotting factors, such as tumor necrosis factor-alpha, interleukin -1beta, C-reactive protein, and fibrinogen owing to vascular infiltration after bacterial invasion or a chronic inflammation of the periodontal tissues. Here, TNF is linked to periodontal disorder.