Von Scholten et al. [20] evaluated the relationship between N-terminal pro-brain natriuretic peptide (NT-proBNP) and CAC score for prognostic purposes in 200 asymptomatic patients with type 2 diabetes and microalbuminuria (considered to be those at highest risk of cardiovascular disease) followed for 6.1 years. This evidence concerns the gene NPPB and cardiovascular disorder.