Milinkovic et al. [28] also reported higher relative gene expression levels of IL-6, IL-17, IL-1β, and TNF-α in 50 peri-implantitis samples compared to 35 healthy implant samples, and significantly higher protein concentrations of IL-6 and IL-17 were detected in 27 peri-implantitis samples in comparison to 27 healthy implant samples. This evidence concerns the gene TNF and Peri-Implantitis.