DPP4 and type 2 diabetes mellitus: Sitagliptin, a DPP-4 inhibitor, was evaluated in a prospective double-blinded clinical cardiovascular safety study (TECOS) in which approximately 14,700 patients with type 2 diabetes with pre-established cardiovascular disease were analyzed [11] Regarding efficacy, the composite endpoint of cardiovascular death, infarction and stroke with sitagliptin was non-inferior to placebo, similar what was demonstrated for saxagliptin, tested in the SAVOR study with more than 16,000 patients [12].