TFPI and lobular neoplasia: Among the proteins assessed, i.e., the d-dimer, tissue factor, tissue factor pathway inhibitor (TFPI), and plasmin and urinary plasmin outperformed the others, showing the strongest correlation with rSLEDAI and the Systemic Lupus International Collaborating Clinics Renal Activity Score (SLICC-RAS) (r = 0.50 and r = 0.58, respectively; p < 0.001), as well as the ability to distinguish active from inactive LN (AUC = 0.86; p < 0.001) [97].