Interestingly, studies conducted by Bruschi et al. revealed a higher prevalence of the anti-ENO-1 IgG2 isotype in LN patients compared with subjects with other glomerulonephritides, as well as in patients with LN, compared with patients with non-renal SLE (AUC = 0.82; p = 0.02) [19,20,21]. Here, ENO1 is linked to systemic lupus erythematosus.