CCL2 and lobular neoplasia: MCP-1 was evaluated in several studies [11,30,41,65,84,85,86,87,88,89,90], and its value as a urinary marker of LN activity was further strengthened in a meta-analysis conducted by Xia et al., which reported a pooled sensitivity of 89% and pooled specificity of 63% (AUC = 0.90; pooled OR = 19.4) for distinguishing patients with active LN from patients with inactive LN [91].