Burbano et al. found a significant increase of MP-HLADR+, MP-high mobility group box 1 (HMGB1)+, and MP-C-X3-C chemokine receptor 1 (CX3CR1)+ in patients with LN compared to patients with non-renal SLE (see Table 1 for the metrics). This evidence concerns the gene HMGB1 and systemic lupus erythematosus.