The situation is different in migraine patients with aura, where there is one new inverse correlation between MMP-9 and IL-8 (rS = −0.37) and one new direct correlation between MMP-9 and PAI-1 (rS = 0.46), but a correlation with TGF-α is less pronounced (rS = 0.45) than in patients without aura (Figure 5A–C). This evidence concerns the gene MMP9 and migraine disorder.