There are also correlations that are present in all migraine patients, but are more pronounced in patients without aura: between PAI-1 and MMP-9, TGF-α; between MMP-9 and PAI-1, TGF-α; between TGF-α and PAI-1, MMP-9, and sICAM-1; as well as between sVCAM-1 and IL-8;. The gene discussed is TGFA; the disease is migraine disorder.