This study showed that four polymorphisms associated with inflammatory response (SNPs of IL-6 (rs1800796), IL-10 (rs1800896), TNF-α (rs1800629), and IFITM3 (rs12252)), were not associated with post-COVID pain in individuals previously hospitalized by COVID-19 at a follow-up period of 18 months. This evidence concerns the gene IL6 and COVID-19.