In animal models of sepsis, which demonstrated a several-foldincrease in plasma histamine, famotidine reduced blood and tissue levels of interleukin-6,interleukin-1β, tumor necrosis factor-α, and their mRNAs, and decreased blood urea nitrogen and serum creatinine [33], whereascimetidine lowered mortality [39]. This evidence concerns the gene IL6 and Sepsis.