P2RY12 and acute coronary syndrome: The TRILOGY-ACS (Targeted Platelet Inhibition to Clarify the Optimal Strategy to Medically Manage Acute Coronary Syndrome) [50] and the ACCOAST (Pretreatment with Prasugrel in Non-ST-Segment Elevation Acute Coronary Syndromes) [54] trials analyzed the significance of prasugrel in NSTEMI patients managed with medical therapy alone and as pretreatment in P2Y12-naive patients, respectively.