In general, inflammatory markers showed promising positive predictive values at optimal cut-offs calculated in the analysis (88.8% for CRP in BP-VP, 98.3% for PCT in BP-AP, and 91.6% for CRP/PCT in VP-AP) at the cost of a low NPV (29.5%, 13.1%, and 40.7%, respectively). Here, CRP is linked to alkaline phosphatase measurement.