Patients with IC/BPS who had an MBC of ≤760 mL had significantly high urinary CXCL-10, MCP-1, eotaxin, IL-6, MIP-1β, RANTES, PGE2, 8-isoprostane levels, and TAC (Table 2). This evidence concerns the gene CCL2 and Bartsocas-Papas syndrome 1.