Angiotensin II, which is involved in pathogenesis of arterial hypertension, elicits the production of reactive oxygen species and modifies the oxidation of LDL, stimulates the expression of vascular cell adhesion molecules and increases the expression of proinflammatory cytokines such as IL-6 [33] and dysregulates circulating miRNAs, which are associated with the presence of PAD and its progression [29]. This evidence concerns the gene IL6 and peripheral arterial disease.