Wright et al., (2008) and Iwata et al., (2009) highlight a key role of gene expression in neutrophils of patients with periodontitis, showing the upregulation of MX1, IFIT4, G1P2, IFIT1, CIG5, and IFI44 and ceruloplasmin genes [30,31]. The gene discussed is RSAD2; the disease is periodontitis.