RIPK2 and periodontitis: Early stages of periodontitis presented hypermethylation in CpGs compared with healthy controls in the promoter regions of the following TLR regulator genes: MAP3K7, MYD88, IL6R, RIPK2, FADD, IRAK1BP1, and PPARA, while advanced stages of periodontitis presented hypomethylation of these genes in comparison to early stages of periodontitis [26].