Using a neonatal rat pup hypoxia model of generalized epilepsy, the whole hippocampus and cortex were analyzed by RNA sequencing; the investigators observed increased expression of canonical Wnt signaling molecule genes such as beta-catenin, LRP6, and Dvl3, as well as inhibitors such as GSK3b, sFRP2, and Wif1. Here, WIF1 is linked to generalized epilepsy.