The most studied molecule of the pathway, KRAS, was found to cause immunosuppression by several mechanisms, for example upregulation of PDL1, infiltration of MDSCs in TME, stimulation of Tregs by secretion of IL-10 and TGF-β1, or downregulation of MHC-I, which impairs the recognition of tumor associated antigens and neoantigens by CD8+ T cells [101,102,103]. Here, CD8A is linked to neoplasm.