These include very-long-chain 3-oxoacyl-CoA reductase proteins, which contribute to the very-long-chain fatty acid biosynthetic process, as well as hydroxymethylglutaryl-CoA synthase, cytosolic fatty acid CoA ligase Acsl3 and cytoplasmic Acetyl-CoA acetyltransferase, all of which play a crucial role in cancer cell metabolism. This evidence concerns the gene ACSL3 and cancer.