Using BerEP4 immunohistochemistry, BCC originates from the basal cell of epidermis, located at the interfollicular epidermis and infundibulum of the hair follicle located along the basal layer, suggesting the notions that BCC originates from the basal cell layer of the interfollicular epidermis, not from the outer root sheath or of the hair follicles. The gene discussed is EPCAM; the disease is skin basal cell carcinoma.