CRH and hypertensive disorder: In contrast, disruptions in malnourished rats of the CRFergic connection from the PVN to the LC with intra-LC α-helical CRF, or the reciprocal noradrenergic connection from the LC to the PVN with intra-PVN prazosin, were both independently capable of suppressing the hypertension and bradycardia in these animals [93].