Besides, both the CRF antagonist α-helical CRH [116] and the CRH1 selective antagonist antalarmin [117] were found to be antihypertensive when administered i.c.v. in acute rat models of hypertension, whereas i.c.v. administered α-helical CRF or injected near the LC did not alter the LC spontaneous neuronal firing rate in normotensive rats [118]. This evidence concerns the gene CRH and Hypertension.