VEGFA and pulmonary arterial hypertension: Second, we determined whether these miRs influence PAH EVs-derived angiogenic and proliferative response within pulmonary endothelium and found that the inhibition of miR-486-5p and overexpression of miR-26a-5p led to the suppression of proliferation as well as VEGF transcripts and protein expression in PAH EVs-induced hPAECs.