In RA, significantly lower IL-10 levels were observed in patients who carried the -1082GG genotype (11.47 ± 32.7 pg/mL) compared to the -1082AA genotype (48.8 ± 60.3 pg/mL, p = 0.046) and heterozygous AG genotype (34.0 ± 50.8 pg/mL, p = 0.036) (Mann–Whitney U test) In healthy women, the -1082GG genotype was linked to a higher IL-10 production (23.7 ± 46.4 pg/mL), however, without reaching statistical significance. This evidence concerns the gene IL10 and rheumatoid arthritis.