IL10 and rheumatoid arthritis: IL-10 is involved in RA immunopathogenesis through many biological functions, including its suppressive effect on the synthesis of proinflammatory cytokines, such as TNF-a, regulation of the Treg and Th1/Th17 balance, and the polarizing of macrophages to M2 phenotype [17] NLRP3 inflammasome activation [18].