NR3C1 and obesity due to melanocortin 4 receptor deficiency: However, upon subsequent analysis, in the Italian Tuscany population, the two T2D-risk variants rs6196 and rs10482633 were in significant LD with the NR3C1-variant rs41423247 (D’ = 0.9, p < 0.0001 and D’ = 1, p < 0.0001, respectively), which is known to be associated with MDD [40], pregnancy-related hyperglycemia [41], metabolic syndrome [34,42], and obesity and impaired glucose tolerance [34], thereby highlighting the potential role of NR3C1 and its reported genetic variants in the mental-metabolic comorbidity.