Of 24 studied variants in the NR3C1 gene, 6 independent single nucleotide polymorphisms (SNPs) were significantly linked to/in LD or associated with T2D (rs6196, rs10482633, rs13186836, rs13184611, rs10482681, and rs258751), and 1 SNP (rs10482668) significantly linked to/in LD or associated with both T2D and MDD (p < 0.05). Here, NR3C1 is linked to major depressive disorder.