Yu et al. revealed that histone lactylation enhances tumorigenesis by promoting transcription of YTH N6-methyladenosine RNA-binding protein 2 (YTHDF2), which recognizes m6A modification sites in the mRNA of two tumor suppressor genes, period1(PER1), and TP53; it promotes their degradation in ocular melanoma [78]. Here, YTHDF2 is linked to ocular melanoma.