Finally, it is interesting to note that Piezo1 ion channels are responsible for cell orientation [28,29] and the regulation of osmolarity [178]; therefore, there is every ground to suspect that the Piezo1 of keratinocytes under the influence of impaired Piezo2 functionality could contribute essentially to dry skin in psoriasis beyond uncontrolled proliferation and differentiation. Here, PIEZO1 is linked to psoriasis.