Overall, the cross-activation of an autoimmune process between psoriatic skin cells, such as keratinocytes, structural Hsp70, and mtHsp70 of somatosensory neurons of the Merkel cell–neurite complex, could be an important link in the autoinflammatory and autoimmune pathomechanism of psoriasis with NKT cell and TLR4/NF-κB signaling pathway involvement. This evidence concerns the gene NFKB1 and psoriasis.