PINK1 and hypertensive disorder: The findings were reported as: (1) hypertension-induced HFpEF impaired mitochondrial fission and led to mitochondrial dysfunctions; (2) In H9C2 cardiomyocytes, PINK1 knockout decreased phosphorylation level of Drp1S616 and mitochondrial localization of Drp1, inhibited mitochondrial fission, and induced mitochondrial dysfunctions; and (3) In HFpEF rats, myocardium-specific overexpression of PINK1 activated Drp1S616 phosphorylation, enhanced mitochondrial fission, and slowed the progression of HFpEF.