DIO2 and hypothyroidism: Thus, the discrepancy in glial reactivity between the C57BL/6J and the WSB/EiJ strains consolidates the link between T3 brain content and neuroinflammation: the local compensatory mechanism of peripheral hypothyroidism via the increase of Dio2 expression would protect the brain of WSB/EiJ mice against low T3 availability and thus, against central inflammation.