The recent study of van Gastel reported that CD45− Ter119− CD31− LepR+ BMSC subpopulations can convert glutamine into aspartate via expressing a high level of aspartate-glutamate transporter SLC1A3, fuel AML cells for pyrimidine generation and protects them against chemotherapy-induced cell death [127]. Here, PECAM1 is linked to acute myeloid leukemia.