MiR-320a interacts with PBX homeobox 3(PBX3) and increases the expression of matrix metallopeptidase 2 (MMP2) and cyclin-dependent kinase 2 (CDK2) by hindering the phosphorylation of ERK1/2, thus increasing the proliferation and metastasis of HCC cells [37]. This evidence concerns the gene MAPK3 and hepatocellular carcinoma.