Furthermore, CCL2 interacts with the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) pathway in a p38-MAPK-dependent manner via forkhead box O1 (FOXO1), which inhibits the release of proinflammatory cytokines and HCC progression. The gene discussed is PTGS2; the disease is hepatocellular carcinoma.