In the luminal B (LumB) subtype of breast cancer, lncRNA LIPR-AS1 cooperative genes IL1R and TGFBR, which are upstream of the MAPK signaling pathway, share a common grade junction pathway (p38 MAPKs-MEF2C), which induces the proliferation, differentiation and apoptosis of cells [114]. Here, IL1R1 is linked to breast carcinoma.