Mechanistically, m6A-dependent TNF receptor-associated factor 4 (TRAF4) expression upregulation by AlkB homolog 5 (ALKHB5) and YTH-domain family 1 (YTHDF1), which thus promoted PPAR-γ degradation by the ubiquitin-proteasome system, contributed to CUR-induced obesity prevention [65]. This evidence concerns the gene TRAF4 and obesity due to melanocortin 4 receptor deficiency.