HMOX1 and fetal growth restriction: Furthermore, a previous study also indicated that dietary CUR supplementation significantly increased body-weight gain, feed intake, antioxidant enzymes activities and nuclear factor, erythroid 2-like 2 (Nrf2) and heme oxygenase-1 (Hmox1) proteins expression, and then efficiently improved the growth and increased hepatic antioxidant capacity of IUGR weaned piglets [45].