ATXN2 and spinocerebellar ataxia type 2: Previously, we showed that expanded ataxin-2 expression in the striatum of wild-type C56BL/6 mice leads to the development of neuropathological hallmarks associated with SCA2, being a suitable model for the study of disease, by displaying features such as neuronal death, neuroinflammation, and autophagy impairment [32].