In this context, we have recently shown that, despite the existence of MDP in house dust mite (HDM) extracts, the lack of NOD2 hindered eosinophil BAL cell recruitment but did not alter the lung cytokine profile, the humoral response, or the AHR in a model of HDM-induced asthma exhibiting a predominant Th2 profile [40]. This evidence concerns the gene NOD2 and asthma.